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TY - JOUR AU - Sani, Umar AU - Yahaya, Musbahu AU - Adam, Dailami S. PY - 2021/03/08 Y2 - 2025/07/18 TI - An Investigation of the Potentials of 2-[(2-Hydroxyphenyl) Methylidene] Hydrazine-1-Carbothioamide and its Mn(II) and Zn(II) Complexes as Antimicrobial Agents JF - Tanzania Journal of Science JA - Tanz. J. Sci. VL - 45 IS - 3 SE - Articles DO - UR - http://www.tjs.udsm.ac.tz/index.php/tjs/article/view/221 SP - 518-526 AB - <p>Antibiotic resistance as a result of misuse, overuse or abuse of drugs is an issue of serious concern world over. The quest for more active and robust antimicrobial agents remains a scientific challenge and requires multimillion-dollar investment in the area of drug design and development. Here in, we report the synthesis and characterisation of a tridentate thiosemicarbazone (2-[(2-hydroxyphenyl)methylidene]hydrazine-1-carbothioamide) (HL) from salicylaldehyde and thiosemicarbazide. Its complexes with Mn(II) and Zn(II) were prepared following similar technique and characterised by melting point, FT-IR, UV –visible spectrophotometry, and elemental analysis. The Mn(II) complex showed paramagnetism with a magnetic moment value of 5.80 BM while the Zn(II) complex was diamagnetic. Both complexes were nonelectrolyte with molar conductivities below 2 ohm^–1cm²mol^–1. The potentials of the compounds as antibacterial and antifungal agents were investigated against three bacterial: <em>Staphylococcus aureus, Escherichia coli and Salmonella typhi</em>, and two fungal: <em>Aspergillus flavus and Mucor indicus</em> isolates. Interestingly, all the compounds showed medium to high activities against the tested isolates (except for the <em>Mucor indicus</em> which resisted all the compounds) and hence their potential as antimicrobial agents.</p> ER -